Lack of association between Helicobacter pylori and laryngeal carcinoma.

OBJECTIVE To survey the role of Helicobacter pylori at the tissue level as a cause of squamous cell carcinoma of the larynx. DESIGN A case-control study. SETTING In an Otolaryngology Ward at an academic university. SUBJECTS Patients with laryngeal cancer as cases and patients with benign laryngeal lesion as controls. MAIN OUTCOME MEASURE In all subjects, specimens of laryngeal tissue were examined by rapid urease test while histopathologic examination was achieved to detect H. Pylori. RESULTS Totally, 44 patients (42 men and 2 women) with squamous cell carcinoma of larynx and 30 patients (24 men and 6 women) with benign laryngeal lesions (polyp, nodule, granuloma) were studied, none of which were infected with the bacterium. CONCLUSION Our results did not show H. Pylori infection among patients with laryngeal cancer (SCC) or benign laryngeal lesions. .